James E Goldman Selected Research

Alexander Disease (Alexander's Disease)

1/2022	Metabolic Enzyme Alterations and Astrocyte Dysfunction in a Murine Model of Alexander Disease With Severe Reactive Gliosis.
11/2019	Site-specific phosphorylation and caspase cleavage of GFAP are new markers of Alexander disease severity.
1/2017	Disorders of Astrocytes: Alexander Disease as a Model.
1/2017	The origin of Rosenthal fibers and their contributions to astrocyte pathology in Alexander disease.
1/2016	Composition of Rosenthal Fibers, the Protein Aggregate Hallmark of Alexander Disease.
5/2014	Astrocytic TDP-43 pathology in Alexander disease.
4/2013	Phenotypic conversions of "protoplasmic" to "reactive" astrocytes in Alexander disease.
7/2012	Splice site, frameshift, and chimeric GFAP mutations in Alexander disease.
4/2010	Oligomers of mutant glial fibrillary acidic protein (GFAP) Inhibit the proteasome system in alexander disease astrocytes, and the small heat shock protein alphaB-crystallin reverses the inhibition.
4/2010	Alexander disease mutant glial fibrillary acidic protein compromises glutamate transport in astrocytes.

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James E Goldman Research Topics

Disease

17	Alexander Disease (Alexander's Disease) 01/2022 - 03/2005
7	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 07/2008
5	Neoplasms (Cancer) 05/2013 - 05/2002
5	Glioma (Gliomas) 02/2011 - 05/2002
3	Gliosis 01/2022 - 11/2016
3	Inflammation (Inflammations) 01/2020 - 04/2002
3	Nervous System Diseases (Neurological Disorders) 06/2008 - 03/2005
2	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2022 - 05/2014
2	COVID-19 01/2022 - 02/2021
2	Disease Progression 10/2019 - 01/2016
2	Stroke (Strokes) 10/2015 - 02/2010
2	Infections 01/2008 - 04/2002
1	Tremor (Tremors) 01/2022
1	Epilepsy (Aura) 01/2022
1	Focal Cortical Dysplasia 01/2022
1	Corticobasal Degeneration 01/2022
1	Paralysis (Palsy) 01/2022
1	Focal cortical dysplasia of Taylor 01/2022
1	Ataxia (Dyssynergia) 01/2022
1	Central Nervous System Infections (Central Nervous System Infection) 01/2020
1	Huntington Disease (Huntington's Disease) 01/2020
1	Lyme Disease (Disease, Lyme) 10/2019
1	Dystonia 12 11/2016
1	Tuberous Sclerosis (Bourneville's Disease) 04/2015
1	Seizures (Absence Seizure) 04/2015
1	Amyloid Plaque 08/2014
1	Frontotemporal Dementia (Semantic Dementia) 05/2014
1	Frontotemporal Lobar Degeneration (Degeneration, Frontotemporal Lobar) 05/2014
1	Hypertrophy 04/2013
1	Brain Neoplasms (Brain Tumor) 02/2011
1	Chromosome Aberrations (Chromosome Abnormalities) 02/2011
1	Glioblastoma (Glioblastoma Multiforme) 02/2011
1	Oligodendroglioma 02/2011
1	Ischemia 02/2010
1	Hyperplasia 01/2008
1	Neuroectodermal Tumors (Neuroectodermal Tumor) 05/2007
1	Lissencephaly 05/2007
1	Neurocytoma 11/2006
1	Astrocytoma (Pilocytic Astrocytoma) 03/2006
1	Demyelinating Diseases (Demyelinating Disease) 05/2004
1	Virus Diseases (Viral Diseases) 04/2002
1	Meningitis 04/2002

Drug/Important Bio-Agent (IBA)

14	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2002
14	Glial Fibrillary Acidic ProteinIBA 01/2022 - 03/2005
4	Protein AggregatesIBA 01/2016 - 03/2005
4	Small Heat-Shock ProteinsIBA 04/2013 - 05/2005
4	Proteasome Endopeptidase Complex (Proteasome)IBA 04/2010 - 12/2006
2	Carrier Proteins (Binding Protein)IBA 01/2022 - 04/2002
2	Odorant Receptors (Odorant Receptor)IBA 01/2022 - 02/2021
2	ORALIT (ORS)IBA 01/2022 - 02/2021
2	Anti-Bacterial Agents (Antibiotics)IBA 01/2020 - 10/2019
2	ChemokinesIBA 10/2015 - 04/2002
2	CytokinesIBA 10/2015 - 05/2009
2	Proto-Oncogene Proteins c-sis (Platelet Derived Growth Factor B)IBA 02/2011 - 07/2010
2	Crystallins (Crystallin)IBA 04/2010 - 05/2005
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 05/2009 - 11/2008
2	TOR Serine-Threonine KinasesIBA 07/2008 - 07/2008
2	p38 Mitogen-Activated Protein KinasesIBA 07/2008 - 06/2008
1	Biological ProductsIBA 01/2022
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2022
1	EnzymesIBA 01/2022
1	RNA (Ribonucleic Acid)IBA 01/2020
1	AcidsIBA 01/2020
1	Angiotensin-Converting Enzyme 2IBA 01/2020
1	CaspasesIBA 11/2019
1	DNA (Deoxyribonucleic Acid)IBA 10/2019
1	AntigensIBA 10/2019
1	Adenosine Triphosphatases (ATPase)IBA 11/2016
1	trans-sodium crocetinate (crocetin)IBA 04/2015
1	Amyloid (Amyloid Fibrils)IBA 08/2014
1	Peptides (Polypeptides)IBA 08/2014
1	DNA-Binding Proteins (DNA Binding Protein)IBA 05/2014
1	Proto-Oncogene Proteins c-metIBA 05/2013
1	Hepatocyte Growth Factor (Growth Factor, Hepatocyte)IBA 05/2013
1	Hemagglutinins (Hemagglutinin)IBA 02/2011
1	Platelet-Derived Growth FactorIBA 07/2010
1	Green Fluorescent ProteinsIBA 07/2010
1	Glutamic Acid (Glutamate)FDA Link 04/2010
1	SilverIBA 02/2010
1	Chemotactic FactorsIBA 05/2009
1	NestinIBA 01/2008
1	Dynactin ComplexIBA 05/2007
1	Dyneins (Dynein)IBA 05/2007
1	Cytoplasmic DyneinsIBA 05/2007
1	Ubiquitinated ProteinsIBA 12/2006
1	NeuregulinsIBA 11/2006
1	MyostatinIBA 11/2006
1	PlectinIBA 03/2006
1	UbiquitinIBA 05/2005
1	CuprizoneIBA 05/2004
1	Protein Isoforms (Isoforms)IBA 05/2002
1	ParaffinIBA 05/2002
1	CC ChemokinesIBA 04/2002

Therapy/Procedure

1	Therapeutics 01/2020
1	Transplantation 02/2011